The safest way to get a permanent tattoo removed is by going to a professional. He or she may use a number of different techniques to remove it, including cryosurgery or laser surgery. In recent years, laser treatment has become the preferred method for tattoo removal. Q-switch lasers are the most common lasers used for this purpose. 
If you are willing to take a chance on other methods, you can try removal creams, salabrasion, or trichloroacetic acid at home. Beware that these techniques are not 100 percent effective and can actually cause other problems, such as infection or rashes.